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1

Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy

Liza Nielsen, Sven Frokjaer, John F. Carpenter, Jens Brange

Journal:

Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 314 KB

english, 2001

2

Protein drug stability: a formulation challenge

Frokjaer, Sven, Otzen, Daniel E.

Journal:

Nature Reviews Drug Discovery

Year:

2005

Language:

english

File:

PDF, 248 KB

english, 2005

3

Chemical and Thermal Stability of Insulin: Effects of Zinc and Ligand Binding to the Insulin Zinc-Hexamer

Kasper Huus, Svend Havelund, Helle B. Olsen, Marco van de Weert, Sven Frokjaer

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 492 KB

english, 2006

4

Thermal Dissociation and Unfolding of Insulin

Huus, Kasper, Havelund, Svend, Olsen, Helle B., van de Weert, Marco, Frokjaer, Sven

Journal:

Year:

2005

Language:

english

File:

PDF, 199 KB

english, 2005

5

125I used for labelling of proteins in an absorption model changes the absorption rate of insulin aspart

Anders Sohoel, Anne Plum, Sven Frokjaer, Peter Thygesen

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 270 KB

english, 2007

6

Effect of tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII

Lotte Krielgaard, Latoya S. Jones, Theodore W. Randolph, Sven Frokjaer, James M. Flink, Mark C. Manning, John F. Carpenter

Journal:

Journal of Pharmaceutical Sciences

Year:

1998

Language:

english

File:

PDF, 231 KB

english, 1998

7

Sustained elevated plasma aprotinin concentration in mice following intraperitoneal injections of w/o emulsions incorporating aprotinin

Simon Bjerregaard, Linda Wulf-Andersen, Ross W. Stephens, Leif Røge Lund, Charlotte Vermehren, Ingrid Söderberg, Sven Frokjaer

Journal:

Journal of Controlled Release

Year:

2001

Language:

english

File:

PDF, 271 KB

english, 2001

8

Effects of Additives on the Stability of Recombinant Human Factor XIII during Freeze-Drying and Storage in the Dried Solid

Lotte Kreilgaard, Sven Frokjaer, James M. Flink, Theodore W. Randolph, John F. Carpenter

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 219 KB

english, 1998

9

The effect of mutations on the structure of insulin fibrils studied by Fourier transform infrared (FTIR) spectroscopy and electron microscopy

Liza Nielsen Garriques, Sven Frokjaer, John F. Carpenter, Jens Brange

Journal:

Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 211 KB

english, 2002

10

Prediction of the association state of insulin using spectral parameters

Vladimir N. Uversky, Liza Nielsen Garriques, Ian S. Millett, Sven Frokjaer, Jens Brange, Sebastian Doniach, Anthony L. Fink

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 332 KB

english, 2003

11

Probing structural changes of proteins incorporated into water-in-oil emulsions

Lene Jorgensen, Marco Van De Weert, Charlotte Vermehren, Simon Bjerregaard, Sven Frokjaer

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 156 KB

english, 2004

12

Micropipette manipulation: A technique to evaluate the stability of water-in-oil emulsions containing proteins

Lene Jorgensen, Dennis Heejong Kim, Charlotte Vermehren, Simon Bjerregaard, Sven Frokjaer

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 215 KB

english, 2004

13

Adsorption of lecithin by cholesterol

Annie Hoelgaard, Sven Frøkjaer

Journal:

Journal of Pharmaceutical Sciences

Year:

1980

Language:

english

File:

PDF, 310 KB

english, 1980

14

Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model

Camilla Foged, Birger Brodin, Sven Frokjaer, Anne Sundblad

Journal:

International Journal of Pharmaceutics

Year:

2005

Language:

english

File:

PDF, 216 KB

english, 2005

15

Computational prediction of solubilizers’ effect on partitioning

Jan Hoest, Inge T. Christensen, Flemming S. Jørgensen, Lars Hovgaard, Sven Frokjaer

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 433 KB

english, 2007

16

Characterisation and physical stability of PEGylated glucagon

Pernille Stigsnaes, Sven Frokjaer, Simon Bjerregaard, Marco van de Weert, Peter Kingshott, E. Horn Moeller

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 593 KB

english, 2007

17

Liposomes for phospholipase A2 triggered siRNA release: Preparation and in vitro test

Camilla Foged, Hanne M. Nielsen, Sven Frokjaer

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 405 KB

english, 2007

18

Association of acylated cationic decapeptides with dipalmitoylphosphatidylserine–dipalmitoylphosphatidylcholine lipid membranes

Tina B. Pedersen, Mads C. Sabra, Sven Frokjaer, Ole G. Mouritsen, Kent Jørgensen

Journal:

Chemistry and Physics of Lipids

Year:

2001

Language:

english

File:

PDF, 247 KB

english, 2001

19

Drug delivery by phospholipase A2 degradable liposomes

Jesper Davidsen, Charlotte Vermehren, Sven Frokjaer, Ole G. Mouritsen, Kent Jørgensen

Journal:

International Journal of Pharmaceutics

Year:

2001

Language:

english

File:

PDF, 63 KB

english, 2001

20

Parenteral water/oil emulsions containing hydrophilic compounds with enhanced in vivo retention: formulation, rheological characterisation and study of in vivo fate using whole body gamma-scintigraphy

Simon Bjerregaard, Heidi Pedersen, Helle Vedstesen, Charlotte Vermehren, Ingrid Söderberg, Sven Frokjaer

Journal:

International Journal of Pharmaceutics

Year:

2001

Language:

english

File:

PDF, 334 KB

english, 2001

21

Release of chemical permeation enhancers from drug-in-adhesive transdermal patches

Michael H Qvist, Ulla Hoeck, Bo Kreilgaard, Flemming Madsen, Sven Frokjaer

Journal:

International Journal of Pharmaceutics

Year:

2002

Language:

english

File:

PDF, 182 KB

english, 2002

22

A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)

Tina B. Pedersen, Sven Frokjaer, Ole G. Mouritsen, Kent Jørgensen

Journal:

International Journal of Pharmaceutics

Year:

2002

Language:

english

File:

PDF, 171 KB

english, 2002

23

Influence of oligopeptide transporter binding affinity upon uptake and transport of d-Asp(OBzl)-Ala and Asp(OBzl)-Sar in filter-grown Caco-2 monolayers

Mitchell E Taub, Bernard A Moss, Bente Steffansen, Sven Frokjaer

Journal:

International Journal of Pharmaceutics

Year:

1997

Language:

english

File:

PDF, 128 KB

english, 1997

24

Drug delivery studies in Caco-2 monolayers. VI. Studies of enzyme substitution therapy for phenylketonuria—a new application of Caco-2 monolayers

Lars Hovgaard, Steffen W Jorgensen, Peter Eigtved, Sven Frokjaer, Helle Brøndsted

Journal:

International Journal of Pharmaceutics

Year:

1998

Language:

english

File:

PDF, 115 KB

english, 1998

25

Oligopeptide transporter mediated uptake and transport of d-Asp(OBzl)-Ala, d-Glu(OBzl)-Ala, and d-Ser(Bzl)-Ala in filter-grown Caco-2 monolayers

Mitchell E Taub, Bernard A Moss, Bente Steffansen, Sven Frokjaer

Journal:

International Journal of Pharmaceutics

Year:

1998

Language:

english

File:

PDF, 121 KB

english, 1998

26

Complex Coacervation of Lysozyme and Heparin: Complex Characterization and Protein Stability

Marco van de Weert, Mia Bendix Andersen, Sven Frokjaer

Journal:

Pharmaceutical Research

Year:

2004

Language:

english

File:

PDF, 97 KB

english, 2004

27

Kinetics of Insulin Adsorption at the Oil–Water Interface and Diffusion Properties of Adsorbed Layers Monitored Using Fluorescence Correlation Spectroscopy

Jesper Donsmark, Lene Jorgensen, Susanne Mollmann, Sven Frokjaer, Christian Rischel

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 509 KB

english, 2006

28

Influence of Acylation on the Adsorption of Insulin to Hydrophobic Surfaces

Charlotte Pinholt, Susanne Hostrup, Jens Thostrup Bukrinsky, Sven Frokjaer, Lene Jorgensen

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 414 KB

english, 2011

29

Association of an acylated model peptide with DPPC–DPPS lipid membranes

Tina B. Pedersen, Mads C. Sabra, Sven Frokjaer, Ole G. Mouritsen, Kent Jørgensen

Journal:

International Journal of Pharmaceutics

Year:

2001

Language:

english

File:

PDF, 69 KB

english, 2001

30

Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid

Lotte Kreilgaard, Sven Frokjaer, James M. Flink, Theodore W. Randolph, John F. Carpenter

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 153 KB

english, 1999

31

Predicting Drug Absorption from Molecular Surface Properties Based on Molecular Dynamics Simulations

Lene Hjorth Krarup, Inge Thøger Christensen, Lars Hovgaard, Sven Frokjaer

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 779 KB

1998

32

The Effect of β-Turn Structure on the Permeation of Peptides Across Monolayers of Bovine Brain Microvessel Endothelial Cells

Mette Sorensen, Betina Steenberg, Gregory T. Knipp, Wen Wang, Bente Steffansen, Sven Frokjaer, Ronald T. Borchardt

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 782 KB

1997

33

Fat Emulsions Based on Structured Lipids (1,3-specific triglycerides): An Investigation of thein VivoFate

Marine Hedeman, Helle Brøndsted, Annette Müllertz, Sven Frokjaer

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 707 KB

1996

34

Transport Characteristics of L-Carnosine and the Anticancer Derivative 4-Toluenesulfonylureido-Carnosine in a Human Epithelial Cell Line

Carsten Uhd Nielsen, Claudiu T. Supuran, Andrea Scozzafava, Sven Frokjaer, Bente Steffansen, Birger Brodin

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

35

Application of confocal laser scanning microscopy in characterization of chemical enhancers in drug-in-adhesive transdermal patches

Michael H. Qvist, Ulla Hoeck, Bo Kreilgaard, Flemming Madsen, Lars Hovgaard, Sven Frokjaer

Journal:

The AAPS Journal

Year:

2002

Language:

english

File:

PDF, 213 KB

english, 2002

36

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

Bente Steffansen, Carsten Uhd Nielsen, Birger Brodin, André Huss Eriksson, Rikke Andersen, Sven Frokjaer

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 224 KB

english, 2004

37

Effects of sucrose on rFVIIa aggregation and methionine oxidation

Susanne Soenderkaer, John F. Carpenter, Marco van de Weert, Lars Lindgaard Hansen, James Flink, Sven Frokjaer

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 161 KB

english, 2004

38

Membrane Transporters

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 24 KB

english, 2004

39

Interfacial adsorption of insulin: Conformational changes and reversibility of adsorption

Susanne H. Mollmann, Lene Jorgensen, Jens T. Bukrinsky, Ulla Elofsson, Willem Norde, Sven Frokjaer

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 334 KB

english, 2006

40

In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

Rikke Andersen, Carsten Uhd Nielsen, Mikael Begtrup, Flemming Steen Jørgensen, Birger Brodin, Sven Frokjaer, Bente Steffansen

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 415 KB

english, 2006

41

Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1

Helle Bach Søndergaard, Silvina A. Bravo, Carsten Uhd Nielsen, Sven Frokjaer, Birger Brodin

Journal:

European Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 1.81 MB

english, 2008

42

Targeting of liposome-associated calcipotriol to the skin: Effect of liposomal membrane fluidity and skin barrier integrity

Nina Østergaard Knudsen, Lene Jorgensen, Jens Hansen, Charlotte Vermehren, Sven Frokjaer, Camilla Foged

Journal:

International Journal of Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 450 KB

english, 2011

43

Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin α2β1 receptor

Nina Ø. Knudsen, Raymond M. Schiffelers, Lene Jorgensen, Jens Hansen, Sven Frokjaer, Camilla Foged

Journal:

International Journal of Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 573 KB

english, 2012

44

Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

Ditte Marie Krohn Jensen, Dongmei Cun, Morten Jonas Maltesen, Sven Frokjaer, Hanne Mørck Nielsen, Camilla Foged

Journal:

Journal of Controlled Release

Year:

2010

Language:

english

File:

PDF, 752 KB

english, 2010

45

Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media

Carsten Uhd Nielsen, Rikke Andersen, Birger Brodin, Sven Frokjaer, Bente Steffansen

Journal:

Journal of Controlled Release

Year:

2001

Language:

english

File:

PDF, 156 KB

english, 2001

46

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

Carsten Uhd Nielsen, Rikke Andersen, Birger Brodin, Sven Frokjaer, Mitchell E Taub, Bente Steffansen

Journal:

Journal of Controlled Release

Year:

2001

Language:

english

File:

PDF, 121 KB

english, 2001

47

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism

Anne Engelbrecht Thomsen, Gerda Marie Friedrichsen, Arne Hagsten Sørensen, Rikke Andersen, Carsten Uhd Nielsen, Birger Brodin, Mikael Begtrup, Sven Frokjaer, Bente Steffansen

Journal:

Journal of Controlled Release

Year:

2003

Language:

english

File:

PDF, 452 KB

english, 2003

48

Erratum to “Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism”: [Journal of Controlled Release 86 (2003) 279–292]☆

Anne Engelbrecht Thomsen, Gerda Marie Friedrichsen, Arne Hagsten Sørensen, Rikke Andersen, Carsten Uhd Nielsen, Birger Brodin, Mikael Begtrup, Sven Frokjaer, Bente Steffansen

Journal:

Journal of Controlled Release

Year:

2003

Language:

english

File:

PDF, 50 KB

english, 2003

49

β-Carboxylic acid esterified d-Asp-Ala retains a high affinity for the oligopeptide transporter in Caco-2 monolayers

Mitchell E. Taub, Bjarne Due Larsen, Bente Steffansen, Sven Frokjaer

Journal:

International Journal of Pharmaceutics

Year:

1997

Language:

english

File:

PDF, 655 KB

english, 1997

50

Stability and in vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter

Eve-Irene Lepist, Tina Kusk, Dorrit H Larsen, Dorthe Andersen, Sven Frokjaer, Mitchell E Taub, Peep Veski, Hans Lennernäs, Gerda Friedrichsen, Bente Steffansen

Journal:

European Journal of Pharmaceutical Sciences

Year:

2000

Language:

english

File:

PDF, 114 KB

english, 2000